Follicular Lymphoma Market to Witness a Steady Growth at a 6.85% CAGR During the Study Period [2018-2030], States DelveInsight

Follicular Lymphoma Market

LAS VEGAS, US  — New explorative therapies such as parsaclisib (Incyte Corporation), zandelisib (ME-401) (MEI Pharma), Breyanzi (Bristol Myers), Betalutin (Nordic Nanovector), odronextamab (REGN1979) (Regeneron Pharmaceuticals), and mosunetuzumab (Roche), are expected to enter the market during the forecasted period. It would be complicated for zandelisib and parsaclisib to distinguish themselves as four therapies targeting PI3K-delta are already approved. Bispecific T cell engager (BiTe) such as mosunetuzumab and ordonextamab are promising as they confer key advantage such as they target two or more antigens simultaneously to exert antitumor effects, their ability to be given off the shelf, and their adaptability in dosing. Besides, with the emergence of CD19 CART therapy, the management of relapsed lymphoid malignancies has transformed with potentially curative therapies on offer to patients who were previously deemed incurable by contemporary therapies. It is anticipated that the launch of these products will fuel the follicular lymphoma market and offer effective curative options to patients.

 

DelveInsight’s “Follicular Lymphoma Market” report provides a thorough comprehension of the Follicular Lymphoma historical and forecasted epidemiology and the Follicular Lymphoma market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan]. The Follicular Lymphoma market report also proffers an analysis of the current Follicular Lymphoma treatment algorithm/practice, market drivers, market barriers, and unmet medical needs.

 

Some of the necessary takeaways from the Follicular Lymphoma Market Research Report

Several key pharmaceutical companies, including Epizyme, Eisai, Bayer Healthcare Pharmaceuticals, Verastem Oncology, Gilead Sciences, TG Therapeutics, ADC Therapeutics, Incyte Corporation, MorphoSys, AbbVie, Janssen Research & Development, Regeneron Pharmaceuticals, Novartis, MEI Pharma, BeiGene, Xynomic Pharmaceuticals, Bristol Myers Squibb, Hoffmann-La Roche, Takeda, and others, are developing novel products to improve the Follicular Lymphoma treatment outlook.
With the recent approval of Yescarta for indolent Follicular Lymphoma, CAR T cells appear promising for the indication. Kymriah (Novartis) and Breyanzi (BMS) are the key CART therapies that are currently in the pipeline for the treatment of patients with relapsed/refractory (R/R) Follicular Lymphoma.
The newer bispecific antibodies (mosunetuzumab and odronextamab) appear to be promising assets, with less toxicity and just easier administration access for patients.
The Follicular Lymphoma market will increase due to changing standards of care, increasing incident cases, and the increasing opportunities in treatment options for Follicular Lymphoma will help boost the market in the forecast period. Nevertheless, Follicular Lymphoma market growth will be impeded by clinical heterogeneity of the disease, economic burden of treatment, and adverse effects impacted by the condition.
Current and future trials will continue to identify innovative treatment approaches that will boost the market size for FL in the upcoming years.

 

For further information on Market Impact by Therapies, visit: Follicular Lymphoma Drugs Market Analysis

 

Follicular Lymphoma is generally an indolent B-cell lymphoproliferative disorder of transformed follicular center B -cells. It is characterized by diffuse lymphadenopathy, bone marrow involvement, and splenomegaly.

DelveInsight estimates that the total Follicular Lymphoma incident cases in the 7MM were 35,737 cases in 2020, out of which the highest cases were observed for the United States.

 

The Follicular Lymphoma Market Analysis Report provides historical as well as forecasted epidemiological analysis segmented into:

Follicular Lymphoma Incident cases
Grade-specific cases of Follicular Lymphoma
Age-specific cases of Follicular Lymphoma
Stage-specific cases of Follicular Lymphoma

 

Get a complete epidemiological segmentation breakdown @ Follicular Lymphoma Epidemiological Analysis

 

Follicular Lymphoma Treatment Market   

Follicular Lymphoma management depends on the disease stage. Options available for the Follicular Lymphoma treatment include radiation (RT), immunochemotherapy (rituximab plus chemotherapy), Bendamustine with immunotherapy, CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) plus obinutuzumab or rituximab, CVP (cyclophosphamide, vincristine, prednisone) plus obinutuzumab or rituximab, immunochemotherapy plus radiation therapy, single-agent rituximab, and observation until progression.

Tazemetostat is the first approved oral Enhancer of zeste homolog 2 (EZH2) inhibitor for relapsed/refractory Follicular Lymphoma after two or more lines of systemic therapy or for Enhancer of zeste homolog 2 wild type or unknown with relapsed/refractory disease in patients who do not have satisfactory alternative options.

In May 2019, a combination of lenalidomide (Revlimid) and rituximab (Rituxan; R2) a treatment option approved for adult patients with grade 1–3A previously treated Follicular Lymphoma. It is a new type of targeted cancer therapy for people with previously treated Follicular Lymphoma. Nevertheless, with the approaching patent expiry, the generic version of lenalidomide will soon hit the market. 

Chimeric antigen receptor (CAR) T-cell therapy has also emerged as an exciting alternative treatment for the patient population. Recently, Gilead subsidiary Kite’s Yescarta has been granted accelerated approval from the US Food and Drug Administration (FDA) for indolent Follicular Lymphoma, becoming the first CAR-T cell therapy approved in this indication.

In September 2017, the US FDA granted accelerated approval to copanlisib (ALIQOPA, Bayer HealthCare Pharmaceuticals Inc.) to treat adult patients with relapsed Follicular Lymphoma. They have received at least two prior systemic therapies.

Furthermore, in September 2018, duvelisib, a PI3k delta inhibitor, received accelerated approval for adult patients with relapsed or refractory Follicular Lymphoma after at least two prior systemic therapies. Nevertheless, the prescribing information contains boxed warnings for fatal and/or severe infections. A recent addition to the armamentarium in the PI3 kinase family is umbralisib that has also been FDA approved for Follicular Lymphoma patients who have received at least three prior lines of therapy.

The armamentarium of Follicular Lymphoma treatment options is continually expanding, with numerous novel therapies attempting to exploit specific biological vulnerabilities. Enrollment in clinical trials evaluating emerging therapies remains a high priority for patients with relapsed/refractory Follicular Lymphoma requiring treatment, especially those who are refractory to both rituximab and alkylating agents (double refractory).

 

Follicular Lymphoma Market Dynamics   

The Follicular Lymphoma market will expand because of the strengthening pipeline. Many pharmaceutical companies are continuously researching and innovating the treatment regimens as monotherapy and combinations for eradicating the current unmet needs in Follicular Lymphoma. The armamentarium of Follicular Lymphoma therapies has expanded, the optimal approach to selecting and sequencing treatments for an individual patient continues to be elucidated. Moreover, validated prognostic methods identifying patients at the time of diagnosis who are at risk of shortened survival could inform therapy selection and clinical trial enrollment, improve stratification and data interpretation and enhance patient counseling.

However, the growth of the Follicular Lymphoma market shall be hindered by the currently used biomarkers, which are not perfectly promising; the standard of care in the first and second-line of therapy, many patients relapse and eventually become refractory to rituximab. Moreover, evolving genetic profile and microenvironment of Follicular Lymphoma tumors contribute to disease progression, maintenance, and development. There is a considerable economic burden, especially in the first year following diagnosis, fewer cost-effectiveness studies, and imperfections reimbursements pose a threat in improving Follicular Lymphoma.

 

Scope of the Follicular Lymphoma Market Insight Report 

Geography Covered: The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
Study Period: 3-year historical and 10-year forecasted analysis (2018-2030).
Follicular Lymphoma Markets Segmentation: By Geographies and By Follicular Lymphoma Therapies (Historical and Forecasted, Current and Upcoming)
Dominant Market Companies investigating its candidates for Follicular Lymphoma: Epizyme, Eisai, Bayer Healthcare Pharmaceuticals, Verastem Oncology, Gilead Sciences, TG Therapeutics, ADC Therapeutics, Incyte Corporation, MorphoSys, AbbVie, Janssen Research & Development, Regeneron Pharmaceuticals, Novartis, MEI Pharma, BeiGene, Xynomic Pharmaceuticals, Bristol Myers Squibb, Hoffmann-La Roche, Takeda, and several others.
Analysis: Comparative and conjoint analysis of emerging therapies.
Case Studies
KOL’s Views
Analyst’s View

 

Table of Contents

1

Follicular Lymphoma Key Insights

2

Follicular Lymphoma Report Introduction 

3

Follicular Lymphoma Market Overview at a Glance      

4

Executive Summary of Follicular Lymphoma

5

Follicular Lymphoma Disease Background and Overview 

6

Follicular Lymphoma Epidemiology and Patient Population

7

Country Wise-Epidemiology of Follicular Lymphoma

7.1

The United States

7.2

EU5 Countries

7.2.1

Germany

7.2.2

France

7.2.3

Italy

7.2.4

Spain

7.2.5

The United Kingdom

7.3

Japan

8

Organizations contributing towards the fight against Follicular Lymphoma

9

Follicular Lymphoma Case Reports

10

Follicular Lymphoma Patient Journey

11

Follicular Lymphoma Marketed Therapies

11.1

 Tazverik (Tazemetostat Hydrobromide): Epizyme|Eisai

11.2

Aliqopa (Copanlisib): Bayer Healthcare Pharmaceuticals

11.3

Copiktra (Duvelisib): Verastem Oncology

11.4

Zydelig (Idelalisib): Gilead Sciences

11.5

Yescarta (Axicabtagene Ciloleucel): Gilead Sciences

11.6

Ukoniq (Umbralisib): TG Therapeutics

11.7

Revlimid (Lenalidomide): Bristol-Myers-Squibb

11.8

Gazyva (Obinutuzumab): Roche

12

Follicular Lymphoma Emerging Therapies

12.1

 Parsaclisib (IBI-376): Incyte Corporation

12.2

Breyanzi (JCAR017): Bristol Myers Squibb

12.3

Zynlonta (Loncastuximab Tesirine): ADC Therapeutics

12.4

Monjuvi (Tafasitamab): Incyte Corporation/MorphoSys

12.5

Imbruvica (Ibrutinib): AbbVie/Janssen Research & Development

12.6

Mosunetuzumab: Roche

12.7

Odronextamab (REGN1979): Regeneron Pharmaceuticals

12.8

Kymriah (Tisagenlecleucel): Novartis

12.9

Zandelisib (ME-401): MEI Pharma

12.10

Brukinsa (Zanubrutinib): BeiGene

13

Other Assets in Development

13.1

Abexinostat (XP-101): Xynomic Pharmaceuticals

13.2

Opdivo (Nivolumab): Bristol Myers Squibb

13.3

Ublituximab (TG-1101): TG Therapeutics

13.4

Tecentriq (Atezolizumab): Hoffmann-La Roche

13.5

Ninlaro (Ixazomib): Takeda

14

Follicular Lymphoma 7MM Market Analysis

14.1

The United States Follicular Lymphoma Market Size

14.2

EU-5 Follicular Lymphoma Market Size

14.2.1

Germany Market Size

14.2.2

France Market Size

14.2.3

Italy Market Size

14.2.4

Spain Market Size

14.2.5

The United Kingdom Market Size

14.2.3

Japan Follicular Lymphoma Market Size

15

Follicular Lymphoma Market Drivers

16

Follicular Lymphoma Market Barriers

17

Follicular Lymphoma SWOT Analysis

18

Follicular Lymphoma Unmet Needs

19

Follicular Lymphoma KOL Views

20

Appendix

21

DelveInsight Capabilities

22

Disclaimer

23

About DelveInsight

 

About DelveInsight

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