The Epilepsy Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.
Some of the key takeaways from the Epilepsy Pipeline Report:
Companies across the globe are diligently working toward developing novel Epilepsy treatment therapies with a considerable amount of success over the years.
Epilepsy companies working in the treatment market are Elium Therapeutics, CombiGene, Ovid Therapeutics, Otsuka Pharmaceutical, SK Biopharmaceuticals, Receptor Life Sciences, Cerebral Therapeutics, Equilibre Biopharmaceuticals, Cerevel Therapeutics, Engrail Therapeutics, Amzell, Xenon Pharma, Engage Therapeutics, Takeda Pharma, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Avicanna, and others, are developing therapies for the Epilepsy treatment
Emerging Epilepsy therapies in the different phases of clinical trials are- Kv7 Program, CG 01, OV329, OPC-214870, SKL24741, RLS103, CT-010, EQU 001, Darigabat, ENX-101, AMZ002, XEN496, Alprazolam inhalation, XEN1101, TAK-935, Cannabidivarin, EQU-001, AVCN-319302, and others are expected to have a significant impact on the Epilepsy market in the coming years.
In January 2023, In order to assess the efficacy and safety of AMZ002 in the treatment of infantile spasms, a rare form of epilepsy, Amzell started a randomised, open-label superiority study. The primary goal of this study is to compare AMZ002 and Vigabatrin for treating infantile spasms (IS) in participants who have just received a diagnosis.
In March 2023, Preclinical data supporting IAMA Therapeutics’ IAMA-6 programme in focal refractory epilepsy will be presented at the 75th American Academy of Neurology (AAN) Annual Meeting, which will be held from April 22–27 in Boston, Massachusetts. IAMA Therapeutics is a preclinical-stage pharmaceutical company focused on the discovery, development, and commercialization of novel medicines to improve the lives of people suffering from brain disorders.
In February 2023, The Phase 2 clinical study of ADX71149 (JNJ-40411813) for the treatment of epilepsy was completed, according to an announcement from Addex Therapeutics. Metabotropic glutamate type 2 (mGlu2) receptor-positive allosteric modulator (PAM) ADX71149 is selective. The experiment is being run by Janssen Pharmaceuticals, Inc., a subsidiary of Johnson & Johnson’s Janssen Pharmaceutical Companies.
In January 2023, EQU-001, a novel anti-inflammatory anti-seizure drug, is administered as once-daily oral adjunctive therapy for focal seizures in adults with epilepsy. Equilibre Biopharmaceuticals Corp. reported positive topline results from the Phase 2 clinical trial evaluating the clinical safety, tolerability, and preliminary efficacy of EQU-001. The EQU-001 study’s findings are positive since they show outstanding tolerability and encouraging efficacy for adult patients with focal epilepsy, particularly for those who have seizures that are challenging to manage.
In January 2023, A cutting-edge electronic diary (eDiary) data capturing technology was launched by Signant Health with the aim of streamlining the epilepsy trial participation experience for patients and research sites while assuring reliable outcome assessment data to support trial endpoints. The novel patient-reported outcome measure, which was created in partnership with The Epilepsy Study Consortium (TESC), offers clinical research sponsors and organisations a standardised way to gather common seizure data items with high-quality data.
In June 2022, Preclinical research from CODA Biotherapeutics, Inc.’s focal epilepsy programme showed that using the company’s lead-engineered receptor and small molecule activator medication considerably decreased the frequency of focal seizures in vivo. The pharmacokinetics of the activator medication in mice models were shown to be consistent with the quick reduction in seizures, according to the results. Data also showed a strong correlation between a decrease in seizure frequency and the expression of CODA’s lead receptor.
In September 2022, In order to investigate the effectiveness of Avicanna’s proprietary formulations in pre-clinical models for epilepsy, Avicanna Inc. is happy to announce that it has expanded its research collaboration in the field of epilepsy with a new collaboration with the University of Toronto and Dr. Mac Burnham’s research team. The efficacy of Avicanna’s medication candidates, including AVCN319302, in animal models for epilepsy will be investigated by the research cooperation headed by Dr. Mac Burnham’s team.
In October 2021, The FDA has given Amzell BV a special protocol assessment for its unique phase III injectable therapy for infantile epilepsy. As an alternative to the current FDA-approved treatment for epileptic seizures, AMZ002 is a sterile injectable hormone that would provide a pure synthetic polypeptide.
In March 2021, A randomised, double-blind, placebo-controlled, parallel-group, multicenter clinical trial was started by Xenon Pharmaceuticals to assess the effectiveness, safety, and tolerability of XEN496 administered as adjunctive treatment in roughly 40 paediatric patients with KCNQ2-DEE aged one month to less than six years.
A chronic neurological condition called epilepsy is characterised by frequent, recurrent convulsions that cause strange behaviour. Due to the many seizure forms, underlying conditions, and varying degrees of severity, it might be seen as a spectrum disorder.
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Emerging Epilepsy Drugs Under Different Phases of Clinical Development Include:
Kv7 Program: Elium Therapeutics
CG 01: CombiGene
OV329: Ovid Therapeutics
OPC-214870: Otsuka Pharmaceutical
SKL24741: SK Biopharmaceuticals
RLS103: Receptor Life Sciences
CT-010: Cerebral Therapeutics
EQU 001: Equilibre Biopharmaceuticals
Darigabat: Cerevel Therapeutics
ENX-101: Engrail Therapeutics
XEN496: Xenon Pharmaceuticals Inc.
Alprazolam inhalation: Engage Therapeutics
XEN1101: Xenon Pharmaceuticals
TAK-935: Takeda Pharmaceuticals
Cannabidivarin: GW Pharmaceuticals
EQU-001: Equilibre Biopharmaceuticals
Epilepsy Route of Administration
Epilepsy pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
Epilepsy Molecule Type
Epilepsy Products have been categorized under various Molecule types, such as
Recombinant fusion proteins
Epilepsy Pipeline Therapeutics Assessment
Epilepsy Assessment by Product Type
Epilepsy By Stage and Product Type
Epilepsy Assessment by Route of Administration
Epilepsy By Stage and Route of Administration
Epilepsy Assessment by Molecule Type
Epilepsy by Stage and Molecule Type
DelveInsight’s Epilepsy Report covers around 90+ products under different phases of clinical development like
Late-stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I)
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates
Route of Administration
Further Epilepsy product details are provided in the report. Download the Epilepsy pipeline report to learn more about the emerging Epilepsy therapies
Some of the key companies in the Epilepsy Therapeutics Market include:
Key companies developing therapies for Epilepsy are – Alexza Pharmaceuticals, Xenon Pharmaceuticals, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Takeda Pharmaceuticals, Abide therapeutics, Otsuka pharmaceutical, H. Lundbeck A/S, Spark Therapeutics, Equilibre Biopharmaceuticals, ES Therapeutics, Supernus Pharmaceuticals, Inc., MGC Pharmaceuticals, Engrail Therapeutics INC, SK biopharmaceuticals, Longboard Pharmaceuticals, Janssen Research & Development, LLC, Equilibre Biopharmaceuticals, Cerevel Therapeutics, LLC, Neurona Therapeutics, Praxis Precision Medicines, UCB Pharma, Receptor Life Sciences, NeuroPro Therapeutics, Inc., Avicanna, Amring Pharmaceuticals Inc., Ovid Therapeutics, Addex Therapeutics, IAMA Therapeutics, CODA Biotherapeutics, Cerebral Therapeutics, Engrail Therapeutics, and others.
Epilepsy Pipeline Analysis:
The Epilepsy pipeline report provides insights into
The report provides detailed insights about companies that are developing therapies for the treatment of Epilepsy with aggregate therapies developed by each company for the same.
It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Epilepsy Treatment.
Epilepsy key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
Epilepsy Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Epilepsy market.
The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.
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Epilepsy Pipeline Market Drivers
Rising awareness and strategic alliance, increasing launch of novel drugs, high burden of epilepsy are some of the important factors that are fueling the Epilepsy Market.
Epilepsy Pipeline Market Barriers
However, loss of patent protection for branded drugs, high cost of treatment and other factors are creating obstacles in the Epilepsy Market growth.
Scope of Epilepsy Pipeline Drug Insight
Key Epilepsy Companies: Elium Therapeutics, CombiGene, Ovid Therapeutics, Otsuka Pharmaceutical, SK Biopharmaceuticals, Receptor Life Sciences, Cerebral Therapeutics, Equilibre Biopharmaceuticals, Cerevel Therapeutics, Engrail Therapeutics, Amzell, Xenon Pharma, Engage Therapeutics, Takeda Pharma, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Avicanna, and others
Key Epilepsy Therapies: Kv7 Program, CG 01, OV329, OPC-214870, SKL24741, RLS103, CT-010, EQU 001, Darigabat, ENX-101, AMZ002, XEN496, Alprazolam inhalation, XEN1101, TAK-935, Cannabidivarin, EQU-001, AVCN-319302, and others
Epilepsy Therapeutic Assessment: Epilepsy current marketed and Epilepsy emerging therapies
Epilepsy Market Dynamics: Epilepsy market drivers and Epilepsy market barriers
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Table of Contents
1. Epilepsy Report Introduction
2. Epilepsy Executive Summary
3. Epilepsy Overview
4. Epilepsy- Analytical Perspective In-depth Commercial Assessment
5. Epilepsy Pipeline Therapeutics
6. Epilepsy Late Stage Products (Phase II/III)
7. Epilepsy Mid Stage Products (Phase II)
8. Epilepsy Early Stage Products (Phase I)
9. Epilepsy Preclinical Stage Products
10. Epilepsy Therapeutics Assessment
11. Epilepsy Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Epilepsy Key Companies
14. Epilepsy Key Products
15. Epilepsy Unmet Needs
16 . Epilepsy Market Drivers and Barriers
17. Epilepsy Future Perspectives and Conclusion
18. Epilepsy Analyst Views
20. About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.
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