Chronic Spontaneous Urticaria Market Insights, Epidemiology Segmentation, and Market Report Scope

DelveInsight added a report on “Chronic Spontaneous Urticaria Market“. It covers an overview, its causes, signs and symptoms, and therapies. Major players are involved in developing therapies for Chronic Spontaneous Urticaria. The launch of emerging therapies will significantly impact the Chronic Spontaneous Urticaria market.

 

Chronic Spontaneous Urticaria Overview

Chronic spontaneous urticaria (CSU) or Chronic Idiopathic urticaria (CIU) is defined as persistent symptoms of urticaria for 6 weeks or more. It is a distressing skin condition that causes red, swollen, itchy and sometimes painful hives or “wheals” on the skin. It is being associated with autoimmunity in almost half of the cases, but the remaining cases still remain “idiopathic,” and all are considered spontaneous. Therefore, the term chronic spontaneous urticaria (CSU) has been employed to indicate chronic urticaria that is endogenous and is independent of any external physical stimulus, which is conceptually helpful and does not imply knowing or not-knowing the cause.

 

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Some of the key features of the Chronic Spontaneous Urticaria Market Report

According to DelveInsight’s analysis, CSU is more prominent in females in comparison to males.
The annual Chronic Spontaneous Urticaria prevalence rates over a 12-year period (2002-2013) were estimated, along with demographic and clinical determinants. The annual prevalence of CSU ranged from 0·02% in 2002 to 0·38% in 2013 in Italy.
Chronic Spontaneous Urticaria companies such as Roche, Novartis, Sanofi Pharmaceutical, AstraZeneca, Kiniksa Pharmaceuticals Ltd, United BioPharma, GlaxoSmithKline, Allakos, Eli Lilly and Company, and several others.
Chronic Spontaneous Urticaria therapies such as XOLAIR, Dupilumab, Ligelizumab, Benralizumab, Fenebrutinib, and several others.

 

Chronic Spontaneous Urticaria Symptoms

Raised or swollen welts on skin
Itching
Swelling
Throat (angioedema)

 

Chronic Spontaneous Urticaria Pathophysiology

The pathophysiology of CSU is not well-understood, but it is clear that derangement of both mast cell and basophil activation and degranulation remains central to the process. Of these, mast cells are most widely accepted as the primary effectors of chronic urticaria. While other cell types, including lymphocytes and poly-mononuclear cells (PMNs), have been observed within the inflammatory infiltrates of patients with CSU.

 

Chronic Spontaneous Urticaria Diagnosis

A potential diagnostic pitfall is the failure to consider a diagnosis of urticarial vasculitis in patients with lesions lasting longer than 24 h, in patients with lesions associated with pain more than with itching, and in patients with lesions resolving with pigmentary changes or scaling. While in most cases, no diagnostic testing may be necessary, targeted laboratory testing based on clinical suspicion is appropriate. In most patients, the only screening tests that are recommended to be performed are a complete blood cell (CBC) count with differential, erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP), liver enzymes, and thyrotropin (TSH).

 

Chronic Spontaneous Urticaria Treatment

Several drugs have been implicated in the treatment of chronic urticaria with evidence ranging from randomized, double-blind placebo-controlled clinical investigations to anecdotal case reports. The newest guidelines recommend a stepwise approach to the pharmacological treatment of chronic urticaria. First-line therapy is nonsedating antihistamines, and if symptoms persist for more than 2 weeks, increasing doses up to fourfold the normal dose is recommended. If the symptoms persist for more than 4 weeks, the guidelines recommend the addition of omalizumab, cyclosporine A or montelukast (not in any preferred order). Other therapeutic options, which have not been included in the guideline, are dapsone, anticoagulants, methotrexate, azathioprine, mycophenolate mofetil, and biologics including intravenous immunoglobulins (IVIGs), rituximab, and adalimumab.

 

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Chronic Spontaneous Urticaria Epidemiology Segmentation

Total Prevalent cases
Age-specific cases
Gender-Specific cases
Total diagnosed and Treatable prevalent cases

 

Chronic Spontaneous Urticaria Treatment Market

The primary principle of treatment of CSU is to eliminate symptoms, including pruritus, wheals, and angioedema. H1-antihistamines function as inverse agonists that combine with and stabilize the inactive conformation of the H1-receptor. The treatment plan for chronic urticaria focuses on the treatment of the identifiable cause, avoidance of aggravating factors, and antihistamines trial. Topical lotions in the form of calamine lotion, menthol with aqueous cream, and crotamiton lotion are useful soothing agents in the treatment. There are few FDA approved therapies for the treatment of CSU.

 

Chronic Spontaneous Urticaria Market Insights

Several drugs have been implicated in the treatment of chronic urticaria with evidence ranging from randomized, double-blind placebo-controlled clinical investigations to anecdotal case reports. The newest guidelines recommend a stepwise approach to the pharmacological treatment of chronic urticaria. First-line therapy is nonsedating antihistamines, and if symptoms persist for more than 2 weeks, increasing doses up to fourfold the normal dose is recommended. If the symptoms persist for more than 4 weeks, the guidelines recommend the addition of omalizumab, cyclosporine A or montelukast (not in any preferred order).

 

Chronic Spontaneous Urticaria Emerging Therapies

Dupilumab
Ligelizumab
Fenebrutinib
MTPS9579A

 

Chronic Spontaneous Urticaria Emerging Therapy Assessment

The market has a promising outlook with many emerging therapies. Some of the major players in the global CSU market in the late phase of clinical development are Novartis {(Ligelizumab), (LOU064)}, Genentech (Fenebrutinib), Sanofi and Regeneron (Dupilumab), and others.

 

Chronic Spontaneous Urticaria Market Drivers

Treatment Side Effects with Currently Available Treatment
Economic Burden on Patients
Increase in Research and Development Activities
Increasing Market Size

 

Chronic Spontaneous Urticaria Market Barriers

Lack of Understanding of Disease Pathology
Approaching Patent Cliff

 

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Chronic Spontaneous Urticaria Market Report Scope

Study Period- 2019-2032
Coverage- The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan
Key Companies: Roche, Novartis, Sanofi Pharmaceutical, AstraZeneca, Kiniksa Pharmaceuticals Ltd, United BioPharma, GlaxoSmithKline, Allakos, Eli Lilly and Company, and several others.
Key Therapies: XOLAIR, Dupilumab, Ligelizumab, Benralizumab, Fenebrutinib, and several others.
Unmet Needs
KOL’s Views
Market Drivers
Market Barriers

 

Table of content

1. Key Insights

2. Executive Summary of Chronic Spontaneous Urticaria

3. Competitive Intelligence Analysis for Chronic Spontaneous Urticaria

4. Chronic Spontaneous Urticaria: Market Overview at a Glance

5. Chronic Spontaneous Urticaria: Disease Background and Overview

6. Patient Journey

7. Chronic Spontaneous Urticaria Epidemiology and Patient Population

8. Treatment Algorithm, Current Treatment, and Medical Practices

9. Chronic Spontaneous Urticaria Unmet Needs

10. Key Endpoints of Chronic Spontaneous Urticaria Treatment

11. Chronic Spontaneous Urticaria Marketed Products

12. Chronic Spontaneous Urticaria Emerging Therapies

13. Chronic Spontaneous Urticaria: Seven Major Market Analysis

14. Attribute analysis

15. 7MM: Market Outlook

16. Access and Reimbursement Overview of Chronic Spontaneous Urticaria

17. KOL Views

18. Market Drivers

19. Market Barriers

20. Appendix

21. DelveInsight Capabilities

22. Disclaimer

23. About DelveInsight

 

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